For children with HIV infection, the FDA approval of the use of raltegravir, an antiretroviral drug that slows the spread of HIV infection, offers a new weapon to treat HIV infection in children.

Many clinical trials in the United States are failing to report their findings in a publicly available database, despite a recent law that compels them to do so, say researchers.

Researchers have shown that it is safe to cut and paste together different viruses in an effort to create the ultimate vehicle for gene therapy. In a phase I clinical trial, the investigators found no side effects from using a "chimeric" virus to deliver replacement genes for an essential muscle ...

A clinical trial comparing prasugrel to clopidogrel for patients with high on-clopidogrel platelet reactivity (HCPR) following percutaneous coronary intervention (PCI) was ended early due to relatively few occurrences of cardiac death or myocardial infarction -- the primary endpoint -- at six month follow up.

A large, international clinical trial indicates that a vaccine to prevent anal cancer is safe and effective, according to a new study.

New research has the potential to revolutionize the treatment of atrial fibrillation, a condition affecting a quarter of a million Canadians which is expected to strike even more in the coming years, as the Canadian population ages.

Drug companies sponsoring human trials of possible new medications have ethical responsibilities to study participants and to science to disclose the results of their clinical research -- even when product development is no longer being pursued.

A large-scale clinical trial evaluating whether daily use of an oral tablet or vaginal gel containing antiretroviral drugs can prevent HIV infection in women is being modified because an interim review found that the study cannot show that one of the study products, oral tenofovir, marketed under the trade name ...

Prior knowledge of phase III clinical trials of new drugs and Food and Drug Administration (FDA) regulatory decisions may affect the price of a drug company's stock according to a new study.

Men with prostate cancer that has spread to other parts of the body and that is resistant to hormone therapy suffer less from fatigue if they are treated with a combination of abiraterone acetate and prednisone, according to a new study. Significant improvements in fatigue are important for this group ...

The first Phase III study of an alpha-pharmaceutical (Radium-223 Chloride -- Alpharadin) in patients with bone metastases from advanced prostate cancer has shown that it can prolong survival significantly. Until now, options for these patients have been very limited. The ALSYMPCA trial had to be stopped early after interim analysis ...

Clinical sites are beginning to enroll patients in a landmark study designed to uncover the molecular segments and variations of multiple myeloma.