An experimental drug targeting a common mutation in melanoma successfully shrank tumors that spread to the brain in nine out of 10 patients in part of an international phase I clinical trial report.

The largest comprehensive analysis of ClinicalTrials.gov finds that clinical trials are falling short of producing high-quality evidence needed to guide medical decision-making. The analysis found the majority of clinical trials is small, and there are significant differences among methodical approaches, including randomizing, blinding and the use of data monitoring committees.

The neuron-killing pathology of Alzheimer’s disease (AD), which begins before clinical symptoms appear, requires the presence of both amyloid-beta (a-beta) plaque deposits and elevated levels of an altered protein called p-tau.

Scientists have found promising effects of a first-in-class targeted cancer drug called BIND-014 in treating solid tumors.

An antioxidant combination of vitamin E, vitamin C and alpha-lipoic acid was not associated with changes in some cerebrospinal fluid biomarkers related to Alzheimer's disease in a randomized controlled trial, according to a new study.

Deep brain stimulation -- also known as DBS -- is effective at improving motor symptoms and quality of life in patients with advanced Parkinson's disease, according to new research.

For children with HIV infection, the FDA approval of the use of raltegravir, an antiretroviral drug that slows the spread of HIV infection, offers a new weapon to treat HIV infection in children.

Many clinical trials in the United States are failing to report their findings in a publicly available database, despite a recent law that compels them to do so, say researchers.

In a study that investigates the challenges of disseminating clinical research findings in peer-reviewed biomedical journals, Yale School of Medicine researchers have found that fewer than half of a sample of trials primarily or partially funded by the National Institutes of Health were published within 30 months of completing the ...

Demographics and clinical factors appear to be associated with survival in patients with Parkinson's disease, and the presence of dementia is associated with a significant increase in mortality, according to a new report.

The American Society of Clinical Oncology has released Clinical Cancer Advances 2011: ASCO's Annual Report on Progress Against Cancer, an independent review of the advances in cancer research that have had the greatest impact on patient care this year. The report also identifies the most promising trends in oncology and ...

Researchers have shown that it is safe to cut and paste together different viruses in an effort to create the ultimate vehicle for gene therapy. In a phase I clinical trial, the investigators found no side effects from using a "chimeric" virus to deliver replacement genes for an essential muscle ...