Interleukin-10 (IL-10) is an anti-inflammatory cytokine protein that reduces immune responses and staves off autoimmune disease. Now, a research team led by Masato Kubo at the RIKEN Research Center for Allergy and Immunology, Yokohama, has identified a transcription factor called E4 promoter-binding protein (E4BP4) that is responsible for driving the ...

Over the past decades, researchers seeking to understand molecular mechanisms underlying various diseases, notably cancer, have taken advantage of DNA microarrays to interrogate tissues specimen of patients for the expression status of thousands of genes at once. Jointly, such gene expression status of each gene in the genome, measured ...

Over the past decades, researchers seeking to understand molecular mechanisms underlying various diseases, notably cancer, have taken advantage of DNA microarrays to interrogate tissues specimen of patients for the expression status of thousands of genes at once. Jointly, such gene expression status of each gene in the genome, measured ...

Over the past decades, researchers seeking to understand molecular mechanisms underlying various diseases, notably cancer, have taken advantage of DNA microarrays to interrogate tissues specimen of patients for the expression status of thousands of genes at once. Jointly, such gene expression status of each gene in the genome, measured ...

(Society for Experimental Biology and Medicine) In the work published in the May 2011 issue of Experimental Biology and Medicine, Dr. Huang and his students, Guo, Feng and Trivedi, offer a first step towards understanding the source of the stable pattern of gene expression profiles by testing whether gene ...

Researchers at the University of Pennsylvania School of Medicine have devised a totally new and far more efficient way of generating induced pluripotent stem cells (iPSCs), immature cells that are able to develop into several different types of cells or tissues in the body. The researchers used fibroblast cells, which ...

Japanese researchers at the RIKEN Plant Science Center (PSC) and the National Institute of Advanced Industrial Science and Technology (AIST) have identified a novel transcription factor controlling how plants dedifferentiate cells in response to wounding.

E2F5 is a member of the E2F transcription factor family, and plays a key role in cell growth and proliferation. Overexpression of E2F5 has been reported in various human cancers, but not in liver cancer, and its biological implication is largely unknown. It is not known whether E2F5 plays a ...

Over expressing a transcription factor that promotes the increase in number of mitochondria greatly improves the neurological function of transgenic mice models for Huntington's disease (HD), researchers told the American Society of Cell Biology's 50th Annual Meeting in Philadelphia. Albert La Spada, M.D., Ph.D., and colleagues at the UC San ...

Over expressing a transcription factor that promotes the increase in number of mitochondria greatly improves the neurological function of transgenic mice models for Huntington's disease (HD), researchers today told the American Society of Cell Biology's 50th Annual Meeting in Philadelphia.

(American Society for Cell Biology) Over expressing a transcription factor that promotes increase in number of mitochondria greatly improves neurological function of transgenic mice models for Huntington's disease.

Retinitis pigmentosa is an inherited eye disorder characterized by progressive loss of vision that in many instances leads to legal blindness at the end stage. In a ChIP-Seq based approach, the researchers identified a key regulatory role of the transcription factor Crx (Cone-rod homeobox) in the expression ...