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Posts tagged: molecular

Molecular Link Established Between Genetic Defect And Heart Malformation

February 8, 2012
UNC researchers have discovered how the genetic defect underlying one of the most common congenital heart diseases keeps the critical organ from developing properly. According to the new research, mutations in a gene called SHP-2 distort the shape of cardiac muscle cells so they are unable to form a fully ...

Molecular path from internal clock to cells controlling rest and activity revealed in new study

February 7, 2012
(PhysOrg.com) -- The molecular pathway that carries time-of-day signals from the body's internal clock to ultimately guide daily behavior is like a black box, says Amita Sehgal, PhD, the John Herr Musser Professor of Neuroscience and Co-Director, Comprehensive Neuroscience Center, at the Perelman School of Medicine, University of Pennsylvania.

Study Identifies Molecular Switch That Allows Melanoma To Resist Therapy

February 7, 2012
The National Cancer Institute (NCI) estimates that as many as one in 51 men and women will be diagnosed with melanoma - the deadliest form of skin cancer - at some point during their lifetimes. A research team led by Ze'ev Ronai, Ph.D. at Sanford-Burnham Medical Research Institute (Sanford-Burnham) is ...

Researchers reveal how molecular imaging can solve breast cancer mysteries

February 7, 2012
In two new studies featured in the February issue of the Journal of Nuclear Medicine, researchers are revealing how molecular imaging can be used to solve mysteries about difficult cases of breast cancer.

Molecular path from internal clock to cells controlling rest and activity

February 7, 2012
(University of Pennsylvania School of Medicine) The molecular pathway that carries time-of-day signals from the body's internal clock to ultimately guide daily behavior is like a black box, says Amita Sehgal, Ph.D. Now, new research from the Sehgal lab is taking a peek inside, describing a molecular pathway and its ...

‘ROCK’ off: Study establishes molecular link between genetic defect and heart malformation

February 6, 2012
CHAPEL HILL, N.C. UNC researchers have discovered how the genetic defect underlying one of the most common congenital heart diseases keeps the critical organ from developing properly. According to the new research, mutations in a gene called SHP-2 distort the shape of cardiac muscle cells so they are ...

‘ROCK’ off: Study establishes molecular link between genetic defect and heart malformation

February 6, 2012
UNC researchers have discovered how the genetic defect underlying one of the most common congenital heart diseases keeps the critical organ from developing properly. According to the new research, mutations in a gene called SHP-2 distort the shape of cardiac muscle cells so they are unable to form a fully ...

‘ROCK’ off: Study establishes molecular link between genetic defect and heart malformation

February 6, 2012
(University of North Carolina School of Medicine) UNC researchers have discovered how the genetic defect underlying one of the most common congenital heart diseases keeps the critical organ from developing properly. According to the new research, mutations in a gene called SHP-2 distort the shape of cardiac muscle cells so ...

Scientists identify molecular switch that controls ATF2′s dual functions

February 3, 2012
The National Cancer Institute (NCI) estimates that as many as one in 51 men and women will be diagnosed with melanoma-the deadliest form of skin cancer-at some point during their lifetimes. A research team led by Ze'ev Ronai, Ph.D. at Sanford-Burnham Medical Research Institute (Sanford-Burnham) is working to unravel the ...

Sanford-Burnham researchers find molecular switch that allows melanoma to resist therapy

February 2, 2012
LA JOLLA, Calif. -- The National Cancer Institute (NCI) estimates that as many as one in 51 men and women will be diagnosed with melanomathe deadliest form of skin cancerat some point during their lifetimes. A research team led by Ze'ev Ronai, Ph.D. at Sanford-Burnham Medical Research Institute (Sanford-Burnham) is ...

Scientists find molecular switch that allows melanoma to resist therapy

February 2, 2012
The National Cancer Institute (NCI) estimates that as many as one in 51 men and women will be diagnosed with melanoma—the deadliest form of skin cancer—at some point during their lifetimes. A research team led by Ze'ev Ronai, Ph.D. at Sanford-Burnham Medical Research Institute (Sanford-Burnham) is working to unravel the ...

Sanford-Burnham researchers find molecular switch that allows melanoma to resist therapy

February 2, 2012
(Sanford-Burnham Medical Research Institute) In a paper published Feb. 3 in Cell, researchers at Sanford-Burnham Medical Research Institute identified a molecular switch that controls the protein Activating Transcription Factor 2 (ATF2), which is associated with poor prognosis in melanoma. This switch is controlled by protein kinase Cε (PKCε), which disables ...