THURSDAY, April 19 (HealthDay News) -- It's not clear whether patients with type 2 diabetes gain any long-term benefit from taking the blood sugar-lowering drug metformin and insulin together rather than insulin alone. That's the conclusion of Danish researchers who reviewed data from 23 clinical trials involving more ...

The impaired substrate metabolism of diabetes patients is often expressed in an increase in fatty deposits in the cells of the heart muscle. Until now, the exact cause of this was unknown. Now, researchers at the MedUni Vienna in the Division of Endocrinology and Metabolism of MedUni Vienna in cooperation ...

In their extraordinary quest to decode human metabolism, researchers at the Salk Institute for Biological Studies have discovered a pair of molecules that regulates the liver's production of glucose - the simple sugar that is the source of energy in human cells and the central player in diabetes. In a ...

Three-dimensional clusters of pancreatic beta-cells that live much longer and secrete more insulin than single cells grown in the laboratory are valuable new tools for studying pancreatic diseases such as diabetes and for testing novel therapies. This cutting-edge advance is described in an article in Tissue Engineering, Part C, Methods, ...

TORONTO, Ont. April 2, 2012 Doctors are more reluctant to start their patients on insulin than the patients are themselves, according to a new study led by researchers at St. Michael's Hospital. "It is well-known that insulin is effective in lowering blood sugar," said Dr. Catherine ...

Doctors are more reluctant to start their patients on insulin than the patients are themselves, according to a new study led by researchers at St. Michael's Hospital. "It is well-known that insulin is effective in lowering blood sugar," said Dr. Catherine Yu, a researcher at the hospital's Keenan Research Centre ...

(St. Michael's Hospital) Doctors are more reluctant to start their patients on insulin than the patients are themselves, according to a new study led by researchers at St. Michael's Hospital.

A Penn- and MIT-led team explained how rapamycin, a drug that extends mouse lifespan, also causes insulin resistance. The researchers showed in an animal model that they could, in principle, separate the effects, which depend on inhibiting two protein complexes, mTORC1 and mTORC2, respectively.

A number of studies have shown that excess insulin circulating in the bloodstream is a major independent risk factor for cardiovascular disease. However, a new study from Joslin Diabetes Center finds that this condition, called hyperinsulinemia, is itself not a cause of atherosclerosis. In humans, insulin resistance, a condition in ...

Researchers at the Institute for Research in Biomedicine (IRB Barcelona) have discovered that deficiency of a single protein, Mitofusin 2, in muscle and hepatic cells of mice is sufficient to cause tissues to become insensitive to insulin, thus producing an increase in blood glucose concentrations. These are the two most ...

A study published early online in JAMA to coincide with its presentation at the American College of Cardiology's annual scientific sessions, reveals that patients with chest pain who received an intravenous solution of glucose-insulin-potassium (GIK) had no reduced risk of progressing to a heart attack and no improved 30-day survival ...

(Joslin Diabetes Center) A new study from Joslin Diabetes Center finds that hyperinsulinemia is itself not a cause of atherosclerosis, as previously thought.