‘Guardian Of The Genome’: Protein Helps Prevent Damaged DNA In Yeast
Working To Understand A Rare Genetic Disease, Scientists Uncover The Most Common Fault In DNA Replication
Scientists from the Medical Research Council (MRC) Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh have discovered an enzyme that corrects the most common mistake in mammalian DNA. The mistake is the inclusion of individual bits of RNA within the DNA sequence, which the researchers found ...
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Focusing on PARP-1 Reveals Potential New Drug Targets
A new study published in Science is shedding light on the molecular details of PARP-1, a DNA damage-detecting enzyme that when inhibited has been shown to be effective in fighting cancer and other diseases. The investigation led by John M. Pascal, Ph.D., an assistant professor in the Department of Biochemistry ...
Gene Expression By Ultraviolet
Imagine being able to control genetic expression by flipping a light switch. Researchers at North Carolina State University are using light-activated molecules to turn gene expression on and off. Their method enables greater precision when studying gene function, and could lead to targeted therapies for diseases like cancer. Triplex-forming oligonucleotides ...
MiR-TRAP Allows Scientists To Better Understand The Roles MicroRNAs Play In Human Development And Disease
Human cells are thought to produce thousands of different microRNAs (miRNAs) - small pieces of genetic material that help determine which genes are turned on or off at a given time. miRNAs are an important part of normal cellular function, but they can also contribute to human disease - some ...
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Parallel Selection Tweaks Many Of The Same Genes To Make Big And Heavy Mice
Organisms are adapted to their environment through their individual characteristics, like body size and body weight. Such complex traits are usually controlled by many genes. As a result, individuals show tremendous variations and can also show subtle gradations. Researchers from the Max Planck Institute for Evolutionary Biology in Plon have ...
How Does A Broken DNA Molecule Get Repaired?
Scientists from the Kavli Institute of Nanoscience at Delft University of Technology have discovered a key element in the mechanism of DNA repair. When the DNA double helix breaks, the broken end goes searching for the similar sequence and uses that as a template for repair. Using a smart new ...
Preventing The Passing Of Mitochondrial Mutations From Mother To Child
Research conducted at the Oregon National Primate Research Center at Oregon Health & Science University helps answer some long-standing questions about how certain disease-causing gene mutations are inherited. The research specifically focused on gene mutations in cell mitochondria that can cause several diseases, including forms of cancer, diabetes, infertility and ...
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