Millennium: The Takeda Oncology Company announced publication of an article in the journal Molecular Cell describing the mechanism of enzyme inhibition of MLN4924-a small molecule inhibitor of the NEDD8-Activating Enzyme (NAE), a key component of a protein homeostasis pathway. MLN4924 is the first small molecule inhibitor that specifically targets this class of enzyme to be studied clinically, and is currently being studied in Phase I clinical trials. NAE is an enzyme that modulates the level of proteins critical for the regulation of cancer cell growth and survival pathways...

Women do better than men after surgical removal of part or all of a cancerous kidney, with fewer post-operative complications, including dying in the hospital, although they are more likely to receive blood transfusions related to their surgery. But Henry Ford Hospital researchers who documented these gender differences can't say ...

Robot-assisted surgery has replaced another minimally invasive operation as the main procedure to treat kidney cancer while sparing part of the diseased organ, and with comparable results, according to a new research study by Henry Ford Hospital urologists. While the study shows that robot-assisted partial nephrectomy (RAPD), available only since ...

A study from Massachusetts General Hospital (MGH) researchers suggests that specific populations of tumor cells have different roles in the process by which tumors make new copies of themselves and grow. In their report in Cancer Cell, researchers identify a tumor-propagating cell required for the growth of a pediatric muscle ...

According to the European Environment Agency (EEA), household products, cosmetics, pharmaceuticals and food all contain endocrine disrupting chemicals (EDCs) which may be causing significant increases in diabetes, obesity, cancers and increasing infertility. In recent decades, the incidence of many human diseases and disorders including diabetes, breast and prostate cancer, ...

Paediatric brain tumours preserve specific characteristics of the normal cells from which they originate - a previously unknown circumstance with ramifications for how tumour cells respond to treatment. This has been shown by Uppsala researcher Fredrik Swartling together with colleagues in the U.S., Canada and England in a study that ...

A new study describes a compound that selectively kills cancer cells by restoring the structure and function of one of the most commonly mutated proteins in human cancer, the "tumor suppressor" p53. The research, published by Cell Press in the May 15th issue of the journal Cancer Cell, uses a ...

New research showing that almost half of 13,000 patients with head and neck cancers had other health-related problems at the same time was one of the presentations in a special session at the 31st conference of the European Society for Radiotherapy and Oncology (ESTRO 31) [1]. The session highlighted the ...